AlphaFold predicted structure
RNF43 · Q68DV7
Mean pLDDT
55.5/ 100
Low
783 residues
Confidence breakdown
- Very high(≥ 90)15%
- Confident(70–90)15%
- Low(50–70)10%
- Very low(< 50)60%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
RNF43
Chr 17q22ring finger protein 43
- Aliases:
- FLJ20315, RNF124, DKFZp781H0392, URCC
- MANE:
- ENST00000407977.7
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Inherited polyposis and early onset colorectal cancer - germline testing
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedGI tract tumours
Disease associations (Open Targets)
sessile serrated polyposis cancer syndrome
0.71pancreatic adenocarcinoma
0.52hyperplastic polyposis syndrome
0.52prostate carcinoma
0.50gastric adenocarcinoma
0.47colorectal adenocarcinoma
0.46exocrine pancreatic carcinoma
0.44colon adenocarcinoma
0.40pancreatic neoplasm
0.39lung carcinoma
0.38
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
E3 ubiquitin-protein ligase RNF43
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)
Diseases associated with RNF43
Curated MONDO disease pages that list RNF43 among their top associated genes.