RNH1

Chr 11p15.5

ribonuclease/angiogenin inhibitor 1

Aliases:: RAI
MANE:: ENST00000354420.7

OMIM: 173320 ↗NCBI: 6050 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

RNH1 · P13489

v62025-08-01

Predicted Aligned Error matrix for RNH1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

96.4/ 100

Very high

461 residues

Confidence breakdown

Very high(≥ 90)98%
Confident(70–90)1%
Low(50–70)0%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

encephalitis, acute, infection-induced, susceptibility to, 12
0.33
hypothyroidism
0.23
Encephalopathy
0.18
nervous system benign neoplasm
0.18
psoriasis
0.10
cancer
0.08
colorectal carcinoma
0.08
COVID-19
0.08
bladder transitional cell carcinoma
0.07
Sepsis
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Ribonuclease H1

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224)