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RNU12

Chr 22q13.2

RNA, U12 small nuclear

Aliases:
RNU12-1
MANE:
ENST00000362512.1

Annotations refreshed 10 hours ago.

Predicted protein structure

No predicted 3D structure for RNU12. Non-coding genes and pseudogenes typically have no protein product.

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

  • Fetal anomalies

    BIALLELIC, autosomal or pseudoautosomal
  • Rare genetic inflammatory skin disorders

    BIALLELIC, autosomal or pseudoautosomal
  • Rare syndromic craniosynostosis or isolated multisuture synostosis

    BIALLELIC, autosomal or pseudoautosomal
  • Ataxia and cerebellar anomalies - narrow panel

    BIALLELIC, autosomal or pseudoautosomal
  • DDG2P

    BIALLELIC, autosomal or pseudoautosomal
  • Early onset or syndromic epilepsy

    BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

  • craniosynostosis-anal anomalies-porokeratosis syndrome

    0.62
  • Craniosynostosis - anal anomalies - porokeratosis

    0.62
  • porokeratosis

    0.37
  • congenital cerebellar ataxia due to RNU12 mutation

    0.37
  • gastric cancer

    0.07
  • neoplasm

    0.04
  • rheumatoid arthritis

    0.02
  • cancer

    0.01
  • type 2 diabetes mellitus

    0.01
  • cerebellar ataxia

    0.00

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.