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RNU5A-1

Chr 15q22.31

RNA, U5A small nuclear 1

Aliases:
U5A, U5B1
MANE:
ENST00000362698.2

Annotations refreshed 9 hours ago.

Predicted protein structure

No predicted 3D structure for RNU5A-1. Non-coding genes and pseudogenes typically have no protein product.

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

  • Fetal anomalies

    MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
  • Early onset or syndromic epilepsy

    MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
  • Intellectual disability

    MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

  • neurodevelopmental disorder

    0.19
  • Neurodevelopmental delay

    0.01
  • neoplasm

    0.01
  • type 2 diabetes mellitus

    0.00
  • heart failure

    0.00
  • acute myocardial infarction

    0.00
  • myocardial infarction

    0.00
  • colonic neoplasm

    0.00
  • malignant colon neoplasm

    0.00
  • hydrops fetalis

    0.00

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.