AlphaFold predicted structure
ROBO2 · Q9HCK4
Mean pLDDT
67.4/ 100
Low
1,378 residues
Confidence breakdown
- Very high(≥ 90)42%
- Confident(70–90)14%
- Low(50–70)3%
- Very low(< 50)40%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ROBO2
Chr 3p12.3roundabout guidance receptor 2
- Aliases:
- KIAA1568
- MANE:
- ENST00000696593.1
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
CAKUT
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedUnexplained kidney failure in young people
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownUnexplained young onset end-stage renal disease - additional genes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
familial vesicoureteral reflux
0.65neurodegenerative disease
0.49Abnormality of the skeletal system
0.43type 2 diabetes mellitus
0.40smoking cessation
0.39colorectal adenocarcinoma
0.34smoking initiation
0.32Proptosis
0.32essential tremor
0.32obesity disorder
0.32
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Roundabout homolog 2
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development
Diseases associated with ROBO2
Curated MONDO disease pages that list ROBO2 among their top associated genes.