ROBO4

Chr 11q24.2

roundabout guidance receptor 4

Aliases:: FLJ20798, MRB, ECSM4
MANE:: ENST00000306534.8

OMIM: 607528 ↗NCBI: 54538 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ROBO4 · Q8WZ75

v62025-08-01

Predicted Aligned Error matrix for ROBO4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

57.3/ 100

Low

1,007 residues

Confidence breakdown

Very high(≥ 90)22%
Confident(70–90)16%
Low(50–70)6%
Very low(< 50)56%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

aortic valve disorder
0.71
Ascending tubular aorta aneurysm
0.42
Bicuspid aortic valve
0.42
familial bicuspid aortic valve
0.38
neurodegenerative disease
0.33
thoracic aortic aneurysm
0.33
cardiac arrest
0.20
congenital diaphragmatic hernia
0.20
familial thoracic aortic aneurysm and aortic dissection
0.18
Rare disease with thoracic aortic aneurysm and aortic dissection
0.17

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Roundabout homolog 4

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415)