AlphaFold predicted structure
ROR1 · Q01973
Mean pLDDT
68.2/ 100
Low
937 residues
Confidence breakdown
- Very high(≥ 90)25%
- Confident(70–90)34%
- Low(50–70)9%
- Very low(< 50)32%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ROR1
Chr 1p31.3ROR family WNT receptor 1
- MANE:
- ENST00000371079.6
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hearing loss, autosomal recessive
0.45Abnormality of the skeletal system
0.39cervical carcinoma
0.37diffuse large B-cell lymphoma
0.36mantle cell lymphoma
0.32thrombophilia
0.29knee fracture
0.29deafness
0.28fracture of pelvis
0.27septic shock
0.26
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Inactive tyrosine-protein kinase transmembrane receptor ROR1
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In the inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling (PubMed:36949068)
Diseases associated with ROR1
Curated MONDO disease pages that list ROR1 among their top associated genes.