RPL17

Chr 18q21.1

ribosomal protein L17

Aliases:: rpL23, L17, uL22
MANE:: ENST00000580261.6

OMIM: 603661 ↗NCBI: 6139 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

RPL17 · P18621

v62025-08-01

Predicted Aligned Error matrix for RPL17 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.9/ 100

Very high

184 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)11%
Low(50–70)7%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Rare anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Duchenne muscular dystrophy
0.50
influenza
0.47
cystic fibrosis
0.39
neuromuscular disease caused by qualitative or quantitative defects of dystrophin
0.32
Becker muscular dystrophy
0.29
Diamond-Blackfan anemia
0.27
macrocytic anemia
0.27
Pancytopenia
0.27
fetal growth restriction
0.27
attention deficit-hyperactivity disorder
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Large ribosomal subunit protein uL22

Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547)