RPL26

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Haematological malignancies cancer susceptibility

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Haematological malignancies for rare disease

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Limb disorders

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Cytopenia - NOT Fanconi anaemia

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Radial dysplasia

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Cytopenias and congenital anaemias

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

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Disease associations (Open Targets)

• Blackfan-Diamond anemia

  0.73

• Diamond-Blackfan anemia

  0.59

• Duchenne muscular dystrophy

  0.50

• acute myeloid leukemia with minimal differentiation

  0.46

• influenza

  0.46

• cystic fibrosis

  0.39

• neuromuscular disease caused by qualitative or quantitative defects of dystrophin

  0.32

• Becker muscular dystrophy

  0.29

• non-Hodgkin lymphoma

  0.11

• aniridia

  0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)