RPL31

Chr 2q11.2

ribosomal protein L31

Aliases:: L31, eL31
MANE:: ENST00000264258.8

OMIM: 617415 ↗NCBI: 6160 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RPL31 · P62899

v62025-08-01

Predicted Aligned Error matrix for RPL31 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.9/ 100

Confident

125 residues

Confidence breakdown

Very high(≥ 90)71%
Confident(70–90)13%
Low(50–70)14%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Haematological malignancies cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Haematological malignancies for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Rare anaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenias and congenital anaemias
Unknown

Disease associations (Open Targets)

Diamond-Blackfan anemia
0.55
Blackfan-Diamond anemia
0.53
Duchenne muscular dystrophy
0.50
influenza
0.46
acute myeloid leukemia with minimal differentiation
0.46
cystic fibrosis
0.39
neuromuscular disease caused by qualitative or quantitative defects of dystrophin
0.32
open-angle glaucoma
0.31
Becker muscular dystrophy
0.29
glaucoma
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Large ribosomal subunit protein eL31

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547)