RPL35A

Chr 3q29

ribosomal protein L35a

Aliases:: L35A, eL33, GIG33
MANE:: ENST00000647248.2

OMIM: 180468 ↗NCBI: 6165 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RPL35A · P18077

v62025-08-01

Predicted Aligned Error matrix for RPL35A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

95.6/ 100

Very high

110 residues

Confidence breakdown

Very high(≥ 90)96%
Confident(70–90)3%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Cytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Haematological malignancies cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Haematological malignancies for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Radial dysplasia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Rare anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Blackfan-Diamond anemia
0.81
Diamond-Blackfan anemia
0.72
inherited bone marrow failure syndrome
0.50
Duchenne muscular dystrophy
0.50
influenza
0.46
neurodegenerative disease
0.46
acute myeloid leukemia with minimal differentiation
0.46
cystic fibrosis
0.39
neuromuscular disease caused by qualitative or quantitative defects of dystrophin
0.32
Becker muscular dystrophy
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Large ribosomal subunit protein eL33

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Required for the proliferation and viability of hematopoietic cells (PubMed:18535205)