RPL3L

Chr 16p13.3

ribosomal protein L3 like

MANE:: ENST00000268661.8

OMIM: 617416 ↗NCBI: 6123 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

RPL3L · Q92901

v62025-08-01

Predicted Aligned Error matrix for RPL3L — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.7/ 100

Very high

407 residues

Confidence breakdown

Very high(≥ 90)92%
Confident(70–90)5%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Paediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
Dilated and arrhythmogenic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

atrial fibrillation
0.48
influenza
0.46
atrial flutter
0.40
familial isolated dilated cardiomyopathy
0.38
dilated cardiomyopathy
0.33
cardiac arrhythmia
0.26
chronic obstructive pulmonary disease
0.25
heart disorder
0.23
cardioembolic stroke
0.22
cardiomyopathy
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Ribosomal protein uL3-like

Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function