RPL9

Chr 4p14

ribosomal protein L9

Aliases:: L9, uL6
MANE:: ENST00000295955.14

OMIM: 603686 ↗NCBI: 6133 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RPL9 · P32969

v62025-08-01

Predicted Aligned Error matrix for RPL9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.1/ 100

Very high

192 residues

Confidence breakdown

Very high(≥ 90)93%
Confident(70–90)6%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Rare anaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Diamond-Blackfan anemia
0.54
Blackfan-Diamond anemia
0.54
Duchenne muscular dystrophy
0.50
influenza
0.46
cystic fibrosis
0.39
neuromuscular disease caused by qualitative or quantitative defects of dystrophin
0.32
Becker muscular dystrophy
0.29
hemorrhoid
0.14
non-Hodgkin lymphoma
0.10
aniridia
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Large ribosomal subunit protein uL6

Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547)