RPS15

Chr 19p13.3

ribosomal protein S15

Aliases:: RIG, MGC111130, S15, uS19
MANE:: ENST00000592588.7

OMIM: 180535 ↗NCBI: 6209 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

RPS15 · P62841

v62025-08-01

Predicted Aligned Error matrix for RPS15 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.4/ 100

Confident

145 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)21%
Low(50–70)12%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Haematological malignancies for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Haematological malignancies cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Duchenne muscular dystrophy
0.50
influenza
0.46
B-cell chronic lymphocytic leukemia
0.39
cystic fibrosis
0.39
COVID-19
0.37
Diamond-Blackfan anemia
0.37
Blackfan-Diamond anemia
0.37
severe acute respiratory syndrome
0.37
neurodegenerative disease
0.33
neuromuscular disease caused by qualitative or quantitative defects of dystrophin
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Small ribosomal subunit protein uS19

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399)