RPS20

Chr 8q12.1

ribosomal protein S20

Aliases:: S20, uS10
MANE:: ENST00000009589.8

OMIM: 603682 ↗NCBI: 6224 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

RPS20 · P60866

v62025-08-01

Predicted Aligned Error matrix for RPS20 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.3/ 100

Confident

119 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)35%
Low(50–70)12%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Diamond-Blackfan anemia
0.55
Blackfan-Diamond anemia
0.54
Duchenne muscular dystrophy
0.50
influenza
0.46
familial colorectal cancer type X
0.40
cystic fibrosis
0.39
COVID-19
0.37
severe acute respiratory syndrome
0.37
neurodegenerative disease
0.35
neuromuscular disease caused by qualitative or quantitative defects of dystrophin
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Small ribosomal subunit protein uS10

Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399)