RRAS

Chr 19q13.33

RAS related

Aliases:: R-Ras, RRAS1
MANE:: ENST00000246792.4

OMIM: 165090 ↗NCBI: 6237 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

RRAS · P10301

v62025-08-01

Predicted Aligned Error matrix for RRAS — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.6/ 100

Confident

218 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)12%
Low(50–70)13%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
RASopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Noonan syndrome
0.42
Noonan syndrome and Noonan-related syndrome
0.37
neurodegenerative disease
0.29
hereditary disease
0.27
hypertensive disorder
0.23
Increased blood pressure
0.17
cardiovascular disorder
0.16
hereditary cancer
0.12
neoplasm
0.09
melanoma
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Ras-related protein R-Ras

GTP-binding protein with GTPase activity, likely involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:39809765). Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267)