AlphaFold predicted structure
RRAS2 · P62070
Mean pLDDT
86.7/ 100
Confident
204 residues
Confidence breakdown
- Very high(≥ 90)72%
- Confident(70–90)9%
- Low(50–70)11%
- Very low(< 50)8%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
RRAS2
Chr 11p15.2RAS related 2
- Aliases:
- TC21
- MANE:
- ENST00000256196.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownMonogenic short stature
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedRASopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFamilial breast cancer
UnknownInherited ovarian cancer (without breast cancer)
Unknown
Disease associations (Open Targets)
Noonan syndrome
0.78noonan syndrome 12
0.69hereditary disease
0.46neurodegenerative disease
0.46ovarian cancer
0.45vitamin D deficiency
0.43vitamin deficiency disorder
0.42endometrial cancer
0.40hypertrophic cardiomyopathy
0.39breast ductal adenocarcinoma
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ras-related protein R-Ras2
GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:31130282, PubMed:31130285, PubMed:39809765). Regulates craniofacial development (PubMed:31130282, PubMed:31130285)
Diseases associated with RRAS2
Curated MONDO disease pages that list RRAS2 among their top associated genes.