RSF1

Chr 11q14.1

remodeling and spacing factor 1

Aliases:: XAP8, RSF-1, p325
MANE:: ENST00000308488.11

OMIM: 608522 ↗NCBI: 51773 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RSF1 · Q96T23

v62025-08-01

Predicted Aligned Error matrix for RSF1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

48.0/ 100

Very low

1,441 residues

Confidence breakdown

Very high(≥ 90)11%
Confident(70–90)9%
Low(50–70)7%
Very low(< 50)73%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

myopathy
0.33
infection
0.25
handedness
0.20
neurodevelopmental disorder
0.19
neoplasm
0.09
esophageal squamous cell carcinoma
0.09
cancer
0.09
non-small cell lung carcinoma
0.08
nasopharyngeal carcinoma
0.08
cervical carcinoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Remodeling and spacing factor 1

Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984)