AlphaFold predicted structure
SALL2 · Q9Y467
Mean pLDDT
50.9/ 100
Low
1,007 residues
Confidence breakdown
- Very high(≥ 90)3%
- Confident(70–90)22%
- Low(50–70)9%
- Very low(< 50)67%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
SALL2
Chr 14q11.2spalt like transcription factor 2
- Aliases:
- KIAA0360, Hsal2, ZNF795
- MANE:
- ENST00000537235.2
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Structural eye disease
BIALLELIC, autosomal or pseudoautosomalOcular coloboma
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
coloboma
0.50coloboma of choroid and retina
0.37coloboma of eye lens
0.37Coloboma of optic papilla
0.37neurodegenerative disease
0.37coloboma of macula
0.37coloboma of optic nerve
0.37coloboma of iris
0.37coloboma of eyelid
0.37cancer
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Sal-like protein 2
Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure