AlphaFold predicted structure
SARS2 · Q9NP81
Mean pLDDT
90.5/ 100
Very high
518 residues
Confidence breakdown
- Very high(≥ 90)83%
- Confident(70–90)7%
- Low(50–70)3%
- Very low(< 50)8%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SARS2
Chr 19q13.2seryl-tRNA synthetase 2, mitochondrial
- Aliases:
- FLJ20450, mtSerRS, SerRSmt, SARS, SERS
- MANE:
- ENST00000221431.11
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalPulmonary arterial hypertension
BIALLELIC, autosomal or pseudoautosomalRenal tubulopathies
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome
0.78inborn mitochondrial metabolism disorder
0.19mitochondrial disease
0.19stricture
0.08type 2 diabetes mellitus
0.06gestational diabetes
0.06neoplasm
0.06infection
0.05COVID-19
0.03viral infectious disease
0.03
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Serine--tRNA ligase, mitochondrial
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)