SCARB1

Chr 12q24.31

scavenger receptor class B member 1

Aliases:: SRB1, CLA-1, CLA1, SR-BI
MANE:: ENST00000261693.11

OMIM: 601040 ↗NCBI: 949 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SCARB1 · Q8WTV0

v62025-08-01

Predicted Aligned Error matrix for SCARB1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.4/ 100

Confident

552 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)20%
Low(50–70)3%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown
Familial hypercholesterolaemia
Likely inborn error of metabolism
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Undiagnosed metabolic disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

coronary artery disorder
0.53
Alzheimer disease
0.53
multiple sclerosis
0.46
neurodegenerative disease
0.46
lysosomal storage disease
0.46
Parkinson disease
0.46
Abnormality of skin pigmentation
0.42
Hypercholesterolemia
0.42
metabolic disease
0.41
myocardial infarction
0.41

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Scavenger receptor class B member 1

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218)