SCARF2

Chr 22q11.21

scavenger receptor class F member 2

Aliases:: SREC-II, SREC2, HUMZD58C02
MANE:: ENST00000622235.5

OMIM: 613619 ↗NCBI: 91179 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SCARF2 · Q96GP6

v62025-08-01

Predicted Aligned Error matrix for SCARF2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.6/ 100

Low

871 residues

Confidence breakdown

Very high(≥ 90)26%
Confident(70–90)21%
Low(50–70)6%
Very low(< 50)47%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
Clefting
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Rare syndromic craniosynostosis or isolated multisuture synostosis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

van den Ende-Gupta syndrome
0.77
Abnormality of the skeletal system
0.54
open-angle glaucoma
0.34
severe acute respiratory syndrome
0.32
COVID-19
0.32
poisoning
0.29
response to xenobiotic stimulus
0.29
neurodegenerative disease
0.27
hereditary disease
0.19
microcephaly
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Scavenger receptor class F member 2

Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity)