SCGN

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Primary immunodeficiency or monogenic inflammatory bowel disease

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• neurodegenerative disease

  0.35

• aging

  0.32

• coronary artery disorder

  0.30

• Epstein-Barr virus infection

  0.28

• type 2 diabetes mellitus

  0.27

• Varicose veins

  0.27

• iron metabolism disease

  0.26

• metabolic dysfunction-associated steatotic liver disease

  0.26

• cervical carcinoma

  0.24

• rheumatoid arthritis

  0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.