AlphaFold predicted structure
SCN10A · Q9Y5Y9
Mean pLDDT
67.3/ 100
Low
1,956 residues
Confidence breakdown
- Very high(≥ 90)12%
- Confident(70–90)48%
- Low(50–70)16%
- Very low(< 50)25%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SCN10A
Chr 3p22.2sodium voltage-gated channel alpha subunit 10
- Aliases:
- Nav1.8, hPN3, SNS, PN3
- MANE:
- ENST00000449082.3
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Hereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownHereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownPain syndromes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownBrugada syndrome and cardiac sodium channel disease
UnknownPaediatric pseudo-obstruction syndrome
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownParoxysmal central nervous system disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownShort QT syndrome
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
episodic pain syndrome, familial, 2
0.72atrial fibrillation
0.71cardiac arrhythmia
0.68sodium channelopathy-related small fiber neuropathy
0.63epilepsy
0.61Pain
0.61bipolar disorder
0.60Seizure
0.60major depressive disorder
0.60migraine disorder
0.60
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Sodium channel protein type 10 subunit alpha
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms
Diseases associated with SCN10A
Curated MONDO disease pages that list SCN10A among their top associated genes.