AlphaFold predicted structure
SDHA · P31040
Mean pLDDT
93.9/ 100
Very high
664 residues
Confidence breakdown
- Very high(≥ 90)92%
- Confident(70–90)1%
- Low(50–70)2%
- Very low(< 50)6%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SDHA
Chr 5p15.33succinate dehydrogenase complex flavoprotein subunit A
- Aliases:
- FP, SDHF
- MANE:
- ENST00000264932.11
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownAdult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
BIALLELIC, autosomal or pseudoautosomalInherited phaeochromocytoma and paraganglioma
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited phaeochromocytoma and paraganglioma excluding NF1
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited predisposition to GIST
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownInherited white matter disorders
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
mitochondrial complex II deficiency, nuclear type 1
0.81pheochromocytoma/paraganglioma syndrome 5
0.79dilated cardiomyopathy 1GG
0.77neurodegeneration with ataxia and late-onset optic atrophy
0.76gastrointestinal stromal tumor
0.74Leigh syndrome
0.73hereditary pheochromocytoma-paraganglioma
0.72familial isolated dilated cardiomyopathy
0.65hereditary neoplastic syndrome
0.57Inherited cancer-predisposing syndrome
0.57
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10746566, PubMed:24781757). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (PubMed:20484225)
Diseases associated with SDHA
Curated MONDO disease pages that list SDHA among their top associated genes.