SEC61B

Chr 9q22.33

SEC61 translocon subunit beta

MANE:: ENST00000223641.5

OMIM: 609214 ↗NCBI: 10952 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SEC61B · P60468

v62025-08-01

Predicted Aligned Error matrix for SEC61B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

57.5/ 100

Low

96 residues

Confidence breakdown

Very high(≥ 90)5%
Confident(70–90)15%
Low(50–70)33%
Very low(< 50)47%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Ductal plate malformation
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Polycystic liver disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodegenerative disease
0.53
asthma
0.37
lower respiratory tract disorder
0.30
hypothyroidism
0.29
cholelithiasis
0.24
Isolated polycystic liver disease
0.19
respiratory system disorder
0.19
polycystic liver disease 1
0.18
mathematical ability
0.15
injury
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein transport protein Sec61 subunit beta

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997)