SECISBP2

Chr 9q22.2

SECIS binding protein 2

Aliases:: SBP2
MANE:: ENST00000375807.8

OMIM: 607693 ↗NCBI: 79048 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SECISBP2 · Q96T21

v62025-08-01

Predicted Aligned Error matrix for SECISBP2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

55.1/ 100

Low

854 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)10%
Low(50–70)7%
Very low(< 50)64%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital hypothyroidism
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Hyperthyroidism
BIALLELIC, autosomal or pseudoautosomal
Thoracic aortic aneurysm or dissection (GMS)
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders

Disease associations (Open Targets)

thyroid hormone metabolism, abnormal 1
0.79
thyroid hormone metabolism, abnormal
0.65
thoracic aortic aneurysm
0.37
poisoning
0.26
hereditary disease
0.19
nephrotic syndrome
0.12
obesity disorder
0.07
Obesity
0.07
obesity due to melanocortin 4 receptor deficiency
0.07
Insulin resistance
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Selenocysteine insertion sequence-binding protein 2

mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277)