SEMA3A

Chr 7q21.11

semaphorin 3A

Aliases:: SEMA1, SemD, coll-1, Hsema-I
MANE:: ENST00000265362.9

OMIM: 603961 ↗NCBI: 10371 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SEMA3A · Q14563

v62025-08-01

Predicted Aligned Error matrix for SEMA3A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.8/ 100

Confident

771 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)14%
Low(50–70)8%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Familial Hirschsprung Disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Hypogonadotropic hypogonadism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Kallmann syndrome
0.53
Abnormality of the skeletal system
0.47
primary angle-closure glaucoma
0.42
alcohol drinking
0.42
open-angle glaucoma
0.40
Brugada syndrome
0.38
congenital heart disease
0.37
skeletal dysplasia
0.37
glaucoma
0.34
urethral syndrome
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Semaphorin-3A

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1