SEMA3F

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Hypogonadotropic hypogonadism (GMS)

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Paediatric pseudo-obstruction syndrome

  Unknown

Disease associations (Open Targets)

• hypogonadotropic hypogonadism

  0.43

• Abnormality of the skeletal system

  0.41

• glaucoma

  0.37

• mathematical ability

  0.37

• Back pain

  0.33

• Alzheimer disease

  0.29

• obesity disorder

  0.26

• smoking initiation

  0.26

• insomnia

  0.24

• osteoarthritis

  0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)