SENP7

Chr 3q12.3

SUMO specific peptidase 7

MANE:: ENST00000394095.7

OMIM: 612846 ↗NCBI: 57337 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SENP7 · Q9BQF6

v62025-08-01

Predicted Aligned Error matrix for SENP7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.1/ 100

Low

1,050 residues

Confidence breakdown

Very high(≥ 90)23%
Confident(70–90)13%
Low(50–70)7%
Very low(< 50)56%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

skin disorder
0.31
actinic keratosis
0.28
arthrogryposis multiplex congenita
0.25
clonal hematopoiesis
0.25
placental abruption
0.24
Recurrent infections
0.23
ovarian neoplasm
0.22
tooth disorder
0.21
skin cancer
0.20
skin neoplasm
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sentrin-specific protease 7

Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 (PubMed:18799455). Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains (PubMed:18799455). Has very low efficiency in processing full-length SUMO proteins to their mature forms (PubMed:18799455)