SERINC3

Chr 20q13.12

serine incorporator 3

Aliases:: DIFF33, TDE, SBBI99, TMS-1, AIGP1
MANE:: ENST00000342374.5

OMIM: 607165 ↗NCBI: 10955 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SERINC3 · Q13530

v62025-08-01

Predicted Aligned Error matrix for SERINC3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.3/ 100

Confident

473 residues

Confidence breakdown

Very high(≥ 90)43%
Confident(70–90)26%
Low(50–70)10%
Very low(< 50)21%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

diabetic ketoacidosis
0.25
psoriasis
0.19
Kallmann syndrome
0.06
hypogonadotropic hypogonadism
0.06
bone Paget disease
0.05
autosomal recessive hypophosphatemic rickets
0.05
Abnormality of the skeletal system
0.05
Autosomal dominant primary hypomagnesemia with hypocalciuria
0.05
hyperostosis corticalis generalisata
0.05
autosomal dominant hypophosphatemic rickets
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine incorporator 3

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505)