SERINC5

Chr 5q14.1

serine incorporator 5

Aliases:: TPO1
MANE:: ENST00000507668.7

OMIM: 614551 ↗NCBI: 256987 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SERINC5 · Q86VE9

v62025-08-01

Predicted Aligned Error matrix for SERINC5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.6/ 100

Confident

423 residues

Confidence breakdown

Very high(≥ 90)37%
Confident(70–90)37%
Low(50–70)9%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

skin disorder
0.28
knee fracture
0.28
skull disorder
0.24
cartilage disease
0.22
connective tissue disorder
0.21
infection
0.10
Abnormality of the gastrointestinal tract
0.06
viral infectious disease
0.04
COVID-19
0.03
DNA methylation
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine incorporator 5

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity (PubMed:37474505). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity)