SERPINB7

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Ichthyosis and erythrokeratoderma

  BIALLELIC, autosomal or pseudoautosomal

• Palmoplantar keratoderma and erythrokeratodermas

  BIALLELIC, autosomal or pseudoautosomal

• Palmoplantar keratodermas

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• palmoplantar keratoderma, Nagashima type

  0.72

• asthma

  0.48

• atopic eczema

  0.47

• childhood onset asthma

  0.40

• Palmoplantar keratoderma

  0.37

• epidermolytic palmoplantar keratoderma, 1

  0.37

• hereditary palmoplantar keratoderma

  0.37

• Eczematoid dermatitis

  0.33

• dermatitis

  0.33

• Allergy

  0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)