SFTPA2

Chr 10q22.3

surfactant protein A2

Aliases:: SP-A2, COLEC5
MANE:: ENST00000372325.7

OMIM: 178642 ↗NCBI: 729238 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SFTPA2 · Q8IWL1

v62025-08-01

Predicted Aligned Error matrix for SFTPA2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.5/ 100

Confident

248 residues

Confidence breakdown

Very high(≥ 90)58%
Confident(70–90)11%
Low(50–70)25%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Childhood interstitial lung disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Familial pulmonary fibrosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Pulmonary fibrosis familial
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

idiopathic pulmonary fibrosis
0.73
interstitial lung disease
0.60
pulmonary fibrosis
0.41
newborn respiratory distress syndrome
0.39
neurodegenerative disease
0.25
hereditary disease
0.19
Mullegama-Klein-Martinez syndrome
0.15
Abnormality of the skeletal system
0.14
infection
0.11
asthma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Pulmonary surfactant-associated protein A2

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration