SFTPB

Chr 2p11.2

surfactant protein B

Aliases:: SP-B
MANE:: ENST00000519937.7

OMIM: 178640 ↗NCBI: 6439 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SFTPB · P07988

v62025-08-01

Predicted Aligned Error matrix for SFTPB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.1/ 100

Confident

381 residues

Confidence breakdown

Very high(≥ 90)16%
Confident(70–90)49%
Low(50–70)16%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Childhood interstitial lung disease
BIALLELIC, autosomal or pseudoautosomal
Familial pulmonary fibrosis
BIALLELIC, autosomal or pseudoautosomal
Pulmonary fibrosis familial
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Neonatal acute respiratory distress with surfactant metabolism deficiency
0.77
surfactant metabolism dysfunction, pulmonary, 1
0.76
Congenital pulmonary alveolar proteinosis
0.64
hereditary pulmonary alveolar proteinosis
0.53
interstitial lung disease
0.40
newborn respiratory distress syndrome
0.40
respiratory distress syndrome in premature infants
0.20
Moderate albuminuria
0.17
alcohol drinking
0.16
acute respiratory distress syndrome
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Pulmonary surfactant-associated protein B

Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter