AlphaFold predicted structure
SGCG · Q13326
Mean pLDDT
80.3/ 100
Confident
291 residues
Confidence breakdown
- Very high(≥ 90)23%
- Confident(70–90)62%
- Low(50–70)7%
- Very low(< 50)8%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SGCG
Chr 13q12.12sarcoglycan gamma
- Aliases:
- SCARMD2, DAGA4, SCG3, DMDA, TYPE
- MANE:
- ENST00000218867.4
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Limb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies
BIALLELIC, autosomal or pseudoautosomalPaediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomalArthrogryposis
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
autosomal recessive limb-girdle muscular dystrophy type 2C
0.80autosomal recessive limb-girdle muscular dystrophy
0.68hereditary disease
0.45limb-girdle muscular dystrophy
0.38Abnormality of the musculature
0.34type 2 diabetes mellitus
0.33atrial fibrillation
0.32premature birth
0.31alcohol drinking
0.30diabetes mellitus
0.29
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Gamma-sarcoglycan
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix
Diseases associated with SGCG
Curated MONDO disease pages that list SGCG among their top associated genes.