SHANK2

Chr 11q13.3-q13.4

SH3 and multiple ankyrin repeat domains 2

Aliases:: CTTNBP1, ProSAP1, SHANK, SPANK-3
MANE:: ENST00000601538.6

OMIM: 603290 ↗NCBI: 22941 ↗Ensembl ↗

Predicted protein structure

AlphaFold predicted structure

SHANK2 · Q9UPX8

v62025-08-01

Predicted Aligned Error matrix for SHANK2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

51.9/ 100

Low

1,849 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)11%
Low(50–70)2%
Very low(< 50)66%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Detailed annotations are loading.

We have HGNC metadata for this gene, but the deeper annotations (ClinVar, gnomAD, PanelApp, …) populate when someone uses the GenoLens extension to look up this gene. Install the extension or check back in a moment.