SIN3A

Chr 15q24.2

SIN3 transcription regulator family member A

Aliases:: KIAA0700, DKFZP434K2235
MANE:: ENST00000394947.8

OMIM: 607776 ↗NCBI: 25942 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SIN3A · Q96ST3

v62025-08-01

Predicted Aligned Error matrix for SIN3A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

68.5/ 100

Low

1,273 residues

Confidence breakdown

Very high(≥ 90)25%
Confident(70–90)34%
Low(50–70)12%
Very low(< 50)29%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Clefting
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

15q24 microdeletion syndrome
0.74
SIN3A-related intellectual disability syndrome
0.62
syndromic intellectual disability
0.55
hereditary disease
0.54
chromosome 15q24 deletion syndrome
0.53
neurodegenerative disease
0.43
Burkitt lymphoma
0.37
autism
0.37
Rett syndrome
0.37
non-Hodgkin lymphoma
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Paired amphipathic helix protein Sin3a

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity)