AlphaFold predicted structure
SIPA1L3 · O60292
Mean pLDDT
55.5/ 100
Low
1,781 residues
Confidence breakdown
- Very high(≥ 90)23%
- Confident(70–90)14%
- Low(50–70)4%
- Very low(< 50)59%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
SIPA1L3
Chr 19q13.13-q13.2signal induced proliferation associated 1 like 3
- Aliases:
- KIAA0545, SPAR3
- MANE:
- ENST00000222345.11
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Bilateral congenital or childhood onset cataracts
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
early-onset non-syndromic cataract
0.56Total congenital cataract
0.39total early-onset cataract
0.37hyperuricemia
0.28prostate carcinoma
0.26cutaneous melanoma
0.24response to antibiotic
0.24poisoning
0.24myeloproliferative disorder
0.24nephrotic syndrome
0.23
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Signal-induced proliferation-associated 1-like protein 3
Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217)