SLC10A7

Chr 4q31.22

solute carrier family 10 member 7

Aliases:: MGC25043, DKFZp566M114, DKFZp313H0531, DKFZp779O2438
MANE:: ENST00000335472.12

OMIM: 611459 ↗NCBI: 84068 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

SLC10A7 · Q0GE19

v62025-08-01

Predicted Aligned Error matrix for SLC10A7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.1/ 100

Confident

340 residues

Confidence breakdown

Very high(≥ 90)42%
Confident(70–90)48%
Low(50–70)8%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Amelogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis
0.77
skeletal dysplasia
0.38
scoliosis
0.37
Short stature
0.37
short stature due to GHSR deficiency
0.37
Cerebral degeneration
0.29
Corneal opacity
0.29
smoking initiation
0.27
alcohol drinking
0.27
infectious disease
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sodium/bile acid cotransporter 7

Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:29878199, PubMed:30082715). Also involved in the regulation of cellular calcium homeostasis (PubMed:30082715, PubMed:31191616). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate)