SLC13A1

Chr 7q31.32

solute carrier family 13 member 1

Aliases:: NaSi-1, NAS1
MANE:: ENST00000194130.7

OMIM: 606193 ↗NCBI: 6561 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC13A1 · Q9BZW2

v62025-08-01

Predicted Aligned Error matrix for SLC13A1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.0/ 100

Confident

595 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)34%
Low(50–70)8%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Monogenic short stature
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

alcohol drinking
0.35
neurodegenerative disease
0.34
hypopituitarism
0.18
diabetes mellitus
0.14
familial idiopathic steroid-resistant nephrotic syndrome
0.07
focal segmental glomerulosclerosis
0.06
Dent disease
0.06
nephrotic syndrome
0.06
hyperprolinemia type 1
0.06
Dent disease type 1
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Solute carrier family 13 member 1

Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:11161786, PubMed:38552027, PubMed:39576865). Can also mediate the transport of selenate and thiosulfate (By similarity)