SLC13A3

Chr 20q13.12

solute carrier family 13 member 3

Aliases:: NADC3, SDCT2
MANE:: ENST00000279027.9

OMIM: 606411 ↗NCBI: 64849 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC13A3 · Q8WWT9

v62025-08-01

Predicted Aligned Error matrix for SLC13A3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.8/ 100

Confident

602 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)29%
Low(50–70)5%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal
White matter disorders and cerebral calcification - narrow panel
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate
0.72
neurodegenerative disease
0.42
autoimmune disorder of central nervous system
0.36
intelligence
0.27
diabetic ketoacidosis
0.25
brain disorder
0.23
placental abruption
0.23
Parkinson disease
0.21
Alzheimer disease
0.21
brain compression
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Na(+)/dicarboxylate cotransporter 3

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10794676, PubMed:10992006, PubMed:15561973, PubMed:17356845, PubMed:17426067, PubMed:24247155, PubMed:30635937, PubMed:39622972). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10794676, PubMed:10992006). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (PubMed:10794676). Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response (PubMed:39116875)