SLC16A1

Chr 1p13.2

solute carrier family 16 member 1

Aliases:: MCT, MCT1
MANE:: ENST00000369626.8

OMIM: 600682 ↗NCBI: 6566 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC16A1 · P53985

v62025-08-01

Predicted Aligned Error matrix for SLC16A1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.1/ 100

Confident

500 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)12%
Low(50–70)3%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital hyperinsulinism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Ketotic hypoglycaemia
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Likely inborn error of metabolism
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Undiagnosed metabolic disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Childhood onset dystonia, chorea or related movement disorder

Disease associations (Open Targets)

exercise-induced hyperinsulinism
0.72
metabolic myopathy due to lactate transporter defect
0.71
ketoacidosis due to monocarboxylate transporter-1 deficiency
0.70
neurodegenerative disease
0.51
inborn errors of metabolism
0.37
Abnormality of refraction
0.25
primary angle-closure glaucoma
0.21
hereditary disease
0.19
refractive error
0.19
neoplasm
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Monocarboxylate transporter 1

Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023)