SLC24A4

Chr 14q32.12

solute carrier family 24 member 4

Aliases:: NCKX4
MANE:: ENST00000532405.6

OMIM: 609840 ↗NCBI: 123041 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC24A4 · Q8NFF2

v62025-08-01

Predicted Aligned Error matrix for SLC24A4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.8/ 100

Confident

622 residues

Confidence breakdown

Very high(≥ 90)17%
Confident(70–90)48%
Low(50–70)12%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Amelogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Hypomaturation amelogenesis imperfecta
0.68
amelogenesis imperfecta
0.65
hair color
0.49
Alzheimer disease
0.44
eye color
0.41
hypocalcified amelogenesis imperfecta
0.37
smoking initiation
0.34
late-onset Alzheimers disease
0.32
ovarian dysfunction
0.31
squamous cell carcinoma
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Sodium/potassium/calcium exchanger 4

Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:12379639, PubMed:26631410). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (By similarity). May play a role in calcium transport during amelogenesis (PubMed:23375655, PubMed:24621671)