SLC25A21

Chr 14q13.3

solute carrier family 25 member 21

Aliases:: ODC1, ODC
MANE:: ENST00000331299.6

OMIM: 607571 ↗NCBI: 89874 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC25A21 · Q9BQT8

v62025-08-01

Predicted Aligned Error matrix for SLC25A21 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.8/ 100

Confident

299 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)39%
Low(50–70)3%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal
Possible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

mitochondrial DNA depletion syndrome 18
0.50
vertebral disorder
0.33
vertebral column disorder
0.33
Paralysis
0.31
Back pain
0.30
urolithiasis
0.30
lobe attachment
0.29
tooth disorder
0.29
vertebral joint disorder
0.27
alcohol drinking
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mitochondrial 2-oxodicarboxylate carrier

Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877). Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877). Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable)