SLC25A24

Chr 1p13.3

solute carrier family 25 member 24

Aliases:: DKFZp586G0123, APC1, SCAMC1, SCAMC-1
MANE:: ENST00000565488.6

OMIM: 608744 ↗NCBI: 29957 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC25A24 · Q6NUK1

v62025-08-01

Predicted Aligned Error matrix for SLC25A24 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.3/ 100

Confident

477 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)47%
Low(50–70)11%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Likely inborn error of metabolism
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Mitochondrial disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Rare syndromic craniosynostosis or isolated multisuture synostosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
Pneumothorax - familial

Disease associations (Open Targets)

Fontaine progeroid syndrome
0.79
Progeroid syndrome, Petty type
0.63
cervical carcinoma
0.33
Bilateral tonic-clonic seizure
0.30
dementia
0.30
viral pneumonia
0.26
hereditary disease
0.19
liver disorder
0.09
pericarditis
0.09
inflammatory bowel disease
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mitochondrial adenyl nucleotide antiporter SLC25A24

Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (PubMed:15123600, PubMed:22015608). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600). May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates (PubMed:22015608, PubMed:29100093)