solute carrier family 25 member 32
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalHereditary ataxia with onset in adulthood
BIALLELIC, autosomal or pseudoautosomalexercise intolerance, riboflavin-responsive
spina bifida
multiple acyl-CoA dehydrogenase deficiency, mild type
folate deficiency
neurodegenerative disease
Familial prostate cancer
prostate cancer
acute tonsillitis
cancer
neoplasm
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Solute carrier family 25 member 32
Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis
SLC25A32 · Q9H2D1
Mean pLDDT
85.3/ 100
Confident
315 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
