SLC25A36

Chr 3q23

solute carrier family 25 member 36

Aliases:: FLJ10618, PNC2
MANE:: ENST00000324194.12

OMIM: 616149 ↗NCBI: 55186 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC25A36 · Q96CQ1

v62025-08-01

Predicted Aligned Error matrix for SLC25A36 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.8/ 100

Confident

311 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)27%
Low(50–70)6%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hyperinsulinemic hypoglycemia, familial, 8
0.57
neurodegenerative disease
0.52
cholelithiasis
0.20
myotonic syndrome
0.20
adolescent idiopathic scoliosis
0.05
hyperinsulinism
0.02
Hyperammonemia
0.02
Acute hepatic failure
0.01
Global developmental delay
0.01
colorectal cancer
0.00

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Solute carrier family 25 member 36

Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports cytosine, guanosine, inosine and uridine (deoxy)nucleoside mono-, di-, and triphosphates by antiport mechanism. Catalyzes uniport at much lower rate (PubMed:25320081). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside mono- and diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration