SLC25A42

Chr 19p13.11

solute carrier family 25 member 42

Aliases:: MGC26694
MANE:: ENST00000318596.8

OMIM: 610823 ↗NCBI: 284439 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC25A42 · Q86VD7

v62025-08-01

Predicted Aligned Error matrix for SLC25A42 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.8/ 100

Very high

318 residues

Confidence breakdown

Very high(≥ 90)79%
Confident(70–90)14%
Low(50–70)4%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Mitochondrial disorders
BIALLELIC, autosomal or pseudoautosomal
Possible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal
Congenital myopathy
BIALLELIC, autosomal or pseudoautosomal
Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

metabolic crises, recurrent, with variable encephalomyopathic features and neurologic regression
0.72
Mitochondrial myopathy
0.53
neurodegenerative disease
0.43
hereditary disease
0.34
inborn mitochondrial myopathy
0.27
gastric cancer
0.07
metabolic disease
0.04
neoplasm
0.02
mitochondrial encephalomyopathy
0.02
Epileptic encephalopathy
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Mitochondrial coenzyme A transporter SLC25A42

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate