SLC26A7

Chr 8q21.3

solute carrier family 26 member 7

Aliases:: SUT2
MANE:: ENST00000276609.8

OMIM: 608479 ↗NCBI: 115111 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

SLC26A7 · Q8TE54

v62025-08-01

Predicted Aligned Error matrix for SLC26A7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.9/ 100

Confident

656 residues

Confidence breakdown

Very high(≥ 90)43%
Confident(70–90)37%
Low(50–70)8%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital hypothyroidism
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

congenital hypothyroidism
0.36
smoking initiation
0.36
acquired thrombocytopenia
0.26
actinic keratosis
0.22
hereditary disease
0.19
bipolar disorder
0.19
Hyperoxaluria
0.12
chronic laryngitis
0.11
androgenetic alopecia
0.10
familial thyroid dyshormonogenesis
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Anion exchange transporter

Acts as an anion channel mediating the transport of chloride, sulfate and oxalate ions (PubMed:11834742). Mediates the transport of bromide, iodide, nitrate, gluconate, thiocyanate and bicarbonate ions (By similarity). Its permeability towards bicarbonate is weak and increases when pH is above 7 (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (By similarity). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:31372509). Although it is an anion channel, according to PubMed:12736153 and PubMed:32119864 it has been shown to exhibit chloride-bicarbonate exchanger activity